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Isoniazid overdosage produces signs and symptoms within 30 minutes to 3 hours.

Thus, there is disagreement over whether or not antibiotic treatment is even necessary for uncomplicated CSD.

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TB can develop through progression of recently acquired infection (primary disease), reactivation of latent infection, or exogenous reinfection.

Instead, when a light is directed into the affected eye, there will only be mild constriction of both pupils or, in the worse case, a converse effect.

Healthcare professionals to teach patients about realistic weight loss goals and to discourage the use of untested and unproven diet products.

The nurse is administering an unpleasant-tasting liquid medication to a 2-year-old child.

Conclusions: Coadministration of rifampin with HIV protease inhibitors may not be a viable treatment option if rifampin administration precedes protease inhibitor initiation.

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Although FIND has negotiated concessionary pricing for public-sector programs in low-income countries and is working to further lower the costs of testing, the costs of instruments and tests will still be considerably higher than those for microscopy, which is all that is currently available in peripheral health care settings in many countries.

Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears.

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Induration must be present; a reddened area is not indicative of a positive reaction.

So, a negative PPD test result does not always mean that a person is free of TB.

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Therefore, it is best not to wear soft contact lenses while taking rifampin, isoniazid, and pyrazinamide.

Rifampin reduces rilpivirine AUC by 80% and trough concentrations by 89%, so the two drugs should not be co-administered.

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To evaluate the interaction between the antibiotic rifampin and the anticoagulant warfarin during chronic therapy, eight normal subjects were given daily doses of warfarin for 21 days to achieve therapeutic hypoprothrombinemia.

The 7-month continuation phase is recommended for the following 3 groups: patients with cavitary pulmonary tuberculosis caused by drug-susceptible organisms and with positive sputum culture at the end of the 2-month initial treatment phase; patients whose initial phase of treatment did not include pyrazinamide; and patients with positive sputum cultures at the end of the initial phase and are treated with isoniazid and rifapentine once weekly for the continuation phase.

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This review will not discuss rifampin use for skin decolonization, leprosy, brucellosis, or noninfectious disease.

These are different diseases, and studies that evaluate the pathophysiology and treatment of one do not necessarily apply to the others.

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Although the lungs are the major site of damage caused by tuberculosis, many other organs and tissues in the body may be affected.

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If the study had not unearthed any benefit from this molecular testing platform, all that would have been demonstrated is the lack of clinical utility of this specific strategy.

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Patients with positive cultures after 4 months of treatment should be considered to have failed treatment (usually as the result of noncompliance or drug-resistant TB).

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