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The Flavivirus genus includes more than 70 single-stranded RNA viruses divided into 8 serogroups ().

Despite being effective against drug resistant parasites, halofantrine is not commonly used in the treatment (prophylactic or therapeutic) of malaria due to its high cost.

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Should circumstances arise wherein Daraprim must be used alone in semi-immune persons, the adult dosage for acute malaria is 50 mg for 2 days; children 4 through 10 years old may be given 25 mg daily for 2 days.

This protein of apparent molecular weight 43 kDa has two possible glycosylation sites, at positions 263 and 345, Three putative palmitoylated cysteine residues are strongly conserved at the C-terminus of E2 for CHIKV and other Alphaviruses (; ) suggesting that these modifications are critical for protein function.

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Six patients withdrew from the study due to adverse events including nausea, vomiting, dizziness, sweating, and disorientation with severe headaches.

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The distribution method used in the trial, which required all participants to attend the health facility on three consecutive days each month for three months, would not be feasible for children living in more distant villages and was problematic for some of those living even quite close to the health centres involved in the trial.

The following advice applies to female travellers who need to take doxycycline for malaria prophylaxis and are taking a combined oral contraceptive pill.

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Although there are several putative sites for phosphorylation within CHIKV nsP3 (S-320 and S-335 amino acids) which are also conserved in ONNV, suggesting that these residues probably control CHIKV nsP3 functions similarly to other alphaviral nsP3 proteins, there is so far no equivalent data available for CHIKV.

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The primary endpoint for the study was the incidence of clinical malaria episodes per year of follow-up.

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