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Given the high frequency of patients who were slow to respond to both key first-line medications, isoniazid and rifampin, and the well-tolerated subsequent increase in levels documented after dose adjustment, TDM appears to be a useful strategy for identifying a remediable cause of slow response at a programmatic level.

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Management should include immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, intensive symptomatic treatment and close medical monitoring, and treatment of any concomitant serious medical problems.

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Topical therapy may be used as both an adjunct to systemic therapy or, in some cases, as the sole therapy for cutaneous skin infections.

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The question of whether synergism can effectively occur in animals was addressed by comparing the drugs efficacies in rescuing critically ill mice.

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Patients received concomitant therapy with at least one DMARD (65.

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Pharmacokinetic interaction between rifampicin and ritonavir-boosted atazanavir in HIV-infected patients.

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Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects.

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Review and recommendations from France regarding monitoring of serum enzymes during therapy of tuberculosis; isoniazid may have direct hepatotoxicity because of dose relatedness and usual absence of recurrence on rechallenge; rifampin is rare cause of liver injury, usually with short latency period; pyrazinamide is clearly hepatotoxic at higher doses which should be kept to a minimum and given for 2 months only).

Although the effect of these changes on antibiotic susceptibility has not been analyzed extensively, it is possible that those metabolic changes may alter the activity of antibiotics such as beta-lactams against bacteria growing during infection.

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The role of chronic hepatitis in isoniazid hepatotoxicity during treatment for latent tuberculosis infection.

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Two of the patients receiving rifampin combination therapy had prosthetic valve endocarditis caused by MRSA, and both died ().

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No, isoniazid-rifampin (Rifamate) is probably not safe to take during pregnancy.

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Risk groups can also be used to describe people who share traits and behaviors that affect their chance of developing a disease.

The present study addresses rifampin-modulated P-gp expression in the duodenum and its consequences for drug disposition.

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In general, the presentation in HIV-infected patients is similar to that seen in HIV-uninfected patients, although the signs and symptoms (such as fevers, weight loss, and malaise) may be attributed to HIV itself and the possibility of TB overlooked.

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